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Showing 1–3 of 3 results
Advanced filters: Author: Silvia Tognetti Clear advanced filters

  • A G1 cell cycle regulatory kinase Cip1 has been identified in budding yeast but how this is regulated is unclear. Here the authors identify cell cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors as regulating Cip1, causing stress induced CDK inhibition and delay in cell cycle progression.

    • Ya-Lan Chang
    • Shun-Fu Tseng
    • Shu-Chun Teng
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.

    • Silvia Tognetti
    • Christian Speck
    News & Views
    Nature Cell Biology
    Volume: 18, P: 593-594