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Showing 1–4 of 4 results
Advanced filters: Author: Sima Porten Clear advanced filters
  • This article provides consensus-based statements from an international panel of bladder cancer experts on the use of active surveillance in non-muscle invasive bladder cancer. Consensus statements cover several aspects of active surveillance, including terminology, eligibility criteria and treatment triggers, providing a framework to guide clinical practice and trial design in this space.

    • Roberto Contieri
    • Paolo Gontero
    • Laura S. Mertens
    Reviews
    Nature Reviews Urology
    P: 1-6
  • Enfortumab vedotin (EV) is the current standard treatment for advanced bladder cancer, but resistance typically develops within a year, highlighting the need for new therapies. This study demonstrates that NECTIN4-targeting CAR T cells are effective against bladder cancer, including EV-resistant cells, and their potency can be further enhanced by using rosiglitazone to boost NECTIN4 expression.

    • Kevin Chang
    • Henry M. Delavan
    • Jonathan Chou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Prostate cancer screening often detects indolent cancers—defined as those which would never cause morbidity or mortality if left undetected and untreated. Unnecessary treatment of indolent cancer is a problem associated with this 'overdetection'. Active surveillance is a management strategy for low-risk cancers which can decrease the overtreatment burden.

    • Jared M. Whitson
    • Sima P. Porten
    • Peter R. Carroll
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 124-125