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Showing 1–4 of 4 results
Advanced filters: Author: Simeon D. Castle Clear advanced filters

  • DNA polymerases are molecular machines that copy genetic material using a template. Here, authors characterize the ability of diverse polymerases to synthesize DNA without a template and show that environmental conditions can alter sequence composition, enabling guided kilobasescale DNA synthesis.

    • Simeon. D. Castle
    • Thea C. T. Irvine
    • Thomas E. Gorochowski
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Evolutionary and rational design approaches are commonly used to engineer biological systems but are typically seen at odds with each other. In this perspective the authors argue for the concept of an evolutionary design spectrum to help unify and compare these design methodologies to support more effective biological engineering.

    • Simeon D. Castle
    • Michiel Stock
    • Thomas E. Gorochowski
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Effective biological engineering requires the acknowledgement of evolution and its consideration during the design process. In this perspective, the authors present the concept of the evotype to reason about and shape the evolutionary potential of natural and engineered biosystems.

    • Simeon D. Castle
    • Claire S. Grierson
    • Thomas E. Gorochowski
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-12