It has been thought that a switch by the muscle from oxidative phosphorylation to glycolysis is associated with the development of insulin resistance. Jiandie Lin and colleagues now show that transgenic mice that undergo this switch, due to modest overexpression of Baf60c, are actually more glucose tolerant and insulin sensitive compared to wild-type mice when both are placed on a high-fat diet, suggesting the switch is actually an adaptive process.
- Zhuo-Xian Meng
- Siming Li
- Jiandie D Lin
