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Showing 1–4 of 4 results
Advanced filters: Author: Simon Delang Clear advanced filters

  • Here, the authors compare seven low passage Zika virus (ZIKV) strains representing the recently circulating viral genetic diversity of African and Asian strains and find that African ZIKV strains have higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice.

    • Fabien Aubry
    • Sofie Jacobs
    • Louis Lambrechts
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification.

    • Wim Dejonghe
    • Sabine Kuenen
    • Eugenia Russinova
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.

    • S. G. P. Funnell
    • W. E. Dowling
    • C. M. Coleman
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 11, P: 1-4

  • The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

    • César Muñoz-Fontela
    • William E. Dowling
    • Dan H. Barouch
    Reviews
    Nature
    Volume: 586, P: 509-515