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Showing 1–4 of 4 results
Advanced filters: Author: Simon Erlendsson Clear advanced filters

  • Arc, a master regulator of synaptic plasticity, can mediate intercellular RNA transfer. Arc evolved from retrotransposon genes. Erlendsson et al. present structures of retroviral-like Arc capsids as a basis to understand their function.

    • Simon Erlendsson
    • Dustin R. Morado
    • John A. G. Briggs
    Research
    Nature Neuroscience
    Volume: 23, P: 172-175

  • The Class 2 family of CRISPR nucleases named Cas12j, which shares only low sequence identity with other CRISPR nucleases was recently identified in the biggiephage clade of phages. Here, the authors present the cryo-EM structure of a functional Cas12j3−crRNA complex in the post-catalytic state and discuss Cas12j3 PAM recognition, hybrid stabilisation and the activation mechanism.

    • Arturo Carabias
    • Anders Fuglsang
    • Guillermo Montoya
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Structures of the assembled matrix protein 1 of influenza A virus in intact virus particles and of oligomers of this protein reconstituted in vitro reveal mechanisms of assembly and disassembly of influenza virus.

    • Julia Peukes
    • Xiaoli Xiong
    • John A. G. Briggs
    Research
    Nature
    Volume: 587, P: 495-498

  • The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic glutamate receptors activation.

    • Troels Rahbek-Clemmensen
    • Matthew D. Lycas
    • Ulrik Gether
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14