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Showing 1–5 of 5 results
Advanced filters: Author: Simon Heeke Clear advanced filters

  • The approval of first line immune checkpoint blockade (ICB) has improved outcomes for patients with metastatic non-small cell lung cancer (mNSCLC), however, whether patients would benefit more from ICB alone or alongside chemotherapy is unclear. Here, the authors develop a machine-learning based approach to help guide individual treatment selection patients with mNSCLC.

    • Maliazurina B. Saad
    • Qasem Al-Tashi
    • Jia Wu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Structural classification of mutations in the epidermal growth factor receptor causing non-small cell lung cancer is a better predictor of patient outcomes following drug treatment than traditional exon-based classification.

    • Jacqulyne P. Robichaux
    • Xiuning Le
    • John V. Heymach
    ResearchOpen Access
    Nature
    Volume: 597, P: 732-737

  • Papillon-Cavanagh et al. evaluate the impact of biopsy site on measurements of tumor mutational burden (TMB) in a large cohort of tumor samples. The authors observe cancer- and tissue-specific patterns in TMB scores, as well as differences in TMB scores between primary and metastatic samples from the same cancer type.

    • Simon Papillon-Cavanagh
    • Julia F. Hopkins
    • Alice M. Walsh
    ResearchOpen Access
    Communications Medicine
    Volume: 1, P: 1-7