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Advanced filters: Author: Simon L. I. J. Denil Clear advanced filters

AQP5 enriches for stem cells and cancer origins in the distal stomach

AQP5 is identified as a marker for pyloric stem cells in humans and mice, and stem cells in the AQP5⁺ compartment are shown to be a source of invasive gastric cancer in mouse models.

Si Hui Tan
Yada Swathi
Nick Barker
Research05 Feb 2020
Nature

Volume: 578, P: 437-443
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach

Leushacke et al. provide insights into the role of Lgr5 cells in the oxyntic stomach, demonstrating that they label a subpopulation of chief cells that function as reserve stem cells during regeneration and cells-of-origin of gastric cancer.

Marc Leushacke
Si Hui Tan
Nick Barker
Research05 Jun 2017
Nature Cell Biology

Volume: 19, P: 774-786
Low-dose calcipotriol can elicit wound closure, anti-microbial, and anti-neoplastic effects in epidermolysis bullosa keratinocytes

Christina Guttmann-Gruber
Birgit Tockner
Josefina Piñón Hofbauer
ResearchOpen Access07 Sept 2018
Scientific Reports

Volume: 8, P: 1-14