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Showing 1–7 of 7 results
Advanced filters: Author: Simon Sedej Clear advanced filters

  • Spermidine, a naturally occurring polyamine, extends the lifespan of mice and is cardioprotective in both aged mice and hypertensive rats. In humans, high dietary spermidine intake is associated with reduced blood pressure and a lower incidence of cardiovascular disease.

    • Tobias Eisenberg
    • Mahmoud Abdellatif
    • Frank Madeo
    Research
    Nature Medicine
    Volume: 22, P: 1428-1438

  • Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

    • Sebastian J. Hofer
    • Ioanna Daskalaki
    • Frank Madeo
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1571-1584

  • Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

    • Didac Carmona-Gutierrez
    • Andreas Zimmermann
    • Frank Madeo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

    • Luca Liberale
    • Simon Tual-Chalot
    • Konstantinos Stellos
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 577-605

  • In this Review, the authors focus on the tight interaction between cardiac mechanics and mitochondrial energetics, discuss how this mechano-energetic coupling is disturbed in various acquired and inherited forms of heart failure, and summarize the established and emerging treatments for heart failure that target this mechano-energetic uncoupling.

    • Dunja Aksentijevic
    • Simon Sedej
    • Christoph Maack
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 773-797

  • In this Review, Kroemer and colleagues describe eight molecular hallmarks of cardiovascular ageing: disabled macroautophagy, loss of proteostasis, genomic instability, epigenetic alterations, mitochondrial dysfunction, cell senescence, dysregulated neurohormonal signalling and inflammation. Therapeutically targeting these hallmarks might attenuate residual cardiovascular risk in older individuals.

    • Mahmoud Abdellatif
    • Peter P. Rainer
    • Guido Kroemer
    Reviews
    Nature Reviews Cardiology
    Volume: 20, P: 754-777