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In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution

A CRISPR-based strategy for screening genes that affect clonal expansion finds that genes that are frequently mutated in squamous cell carcinoma converge on a TNF signalling module involving macrophages.

Peter F. Renz
Umesh Ghoshdastider
Ataman Sendoel
ResearchOpen Access17 Jul 2024
Nature

Volume: 632, P: 419-428
Signature of long-lived memory CD8⁺ T cells in acute SARS-CoV-2 infection

Evidence of a transcriptional signature that marks precursors of long-lived CD8⁺ memory T cells in SARS-CoV-2 infection.

Sarah Adamo
Jan Michler
Onur Boyman
ResearchOpen Access07 Dec 2021
Nature

Volume: 602, P: 148-155
RNA sequencing of blood from sex- and age-matched discordant siblings supports immune and transcriptional dysregulation in autism spectrum disorder

Pasquale Tomaiuolo
Ignazio Stefano Piras
Antonio M. Persico
ResearchOpen Access16 Jan 2023
Scientific Reports

Volume: 13, P: 1-11