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Advanced filters: Author: Simona Infantino Clear advanced filters

  • PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

    • Simona Infantino
    • Amanda Light
    • David Tarlinton
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Expression of a competent Igh heavy chain initiates a pre-BCR checkpoint during B cell development. Reth and colleagues show that protein arginine methylation by a BTG2-PRMT1 complex is required to inactivate CDK4 and thereby establish pre-B cell arrest.

    • Elmar Dolezal
    • Simona Infantino
    • Michael Reth
    Research
    Nature Immunology
    Volume: 18, P: 911-920