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Showing 1–4 of 4 results
Advanced filters: Author: Simona Punzi Clear advanced filters

  • Bacteria are able to withstand antibiotic treatment through three mechanisms, resistance, persistence or tolerance. Here, the authors investigate whether such mechanisms as defined in bacteria also apply to human cancer cells, finding that exposure to chemotherapy elicits an atavistic tolerant response in human cancer cells, providing key survival advantages.

    • Simona Punzi
    • Davide Cittaro
    • Giovanni Tonon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Caloric restriction (CR) has been demonstrated to have a role in tumour growth and therapy response but its effects on cancer stem cells are less known. Here, in Acute Promyelocytic Leukemia, the authors show that despite initial anti-tumour effect, CR drives the selection of leukaemia-initiating cells resulting in relapse which could be prevented by ablation of LSD1.

    • Rani Pallavi
    • Elena Gatti
    • Pier Giuseppe Pelicci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Phylogenetic analysis is used to identify transmission chains, but no software is available for the automated partition of large phylogenies. Prosperiet al. apply a new search algorithm to identify transmission clusters within the phylogeny of HIV-1gene sequences linking molecular and epidemiological data.

    • Mattia C.F. Prosperi
    • Massimo Ciccozzi
    • Andrea De Luca
    Research
    Nature Communications
    Volume: 2, P: 1-10