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Showing 1–3 of 3 results
Advanced filters: Author: Simona Valletta Clear advanced filters

  • Carlo Gambacorti-Passerini and colleagues identify recurrent SETBP1 mutations in atypical chronic myeloid leukemia. The mutations, which cluster in a small region of SETBP1, are associated with high white blood cell counts and poor prognosis.

    • Rocco Piazza
    • Simona Valletta
    • Carlo Gambacorti-Passerini
    Research
    Nature Genetics
    Volume: 45, P: 18-24

  • Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoietic defects, re-balancing haematopoietic stem cell lineage output.

    • Simona Valletta
    • Alexander Thomas
    • Claus Nerlov
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Meng et al. report that lymphoid fate is programmed epigenetically rather than transcriptionally in haematopoietic stem cells and shed light on how epigenetic programming generates platelet differentiation pathways with distinct kinetics.

    • Yiran Meng
    • Joana Carrelha
    • Claus Nerlov
    Research
    Nature Cell Biology
    Volume: 25, P: 812-822