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Showing 1–2 of 2 results
Advanced filters: Author: Simone Culurgioni Clear advanced filters

  • LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.

    • Laura Pirovano
    • Simone Culurgioni
    • Marina Mapelli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetric fate specification independently of microtubule motors.

    • Simone Culurgioni
    • Sara Mari
    • Marina Mapelli
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13