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Showing 1–3 of 3 results
Advanced filters: Author: Simone Joas Clear advanced filters

  • In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al. incorporate two putative HIV virulence factors into SIV and study effects in infected monkeys, suggesting that species-specific host factors are responsible for HIV pathogenesis.

    • Simone Joas
    • Erica H. Parrish
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.

    • Janis A. Müller
    • Mirja Harms
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The interferon-inducible RNA-binding protein N4BP1 binds to and degrades HIV-1 mRNAs, thus inhibiting viral degradation and promoting viral latency. However, metacaspase-mediated degradation of N4BP1 following activation of CD4+ T cells facilitates HIV-1 latency reversal.

    • Daichi Yamasoba
    • Kei Sato
    • Osamu Takeuchi
    Research
    Nature Microbiology
    Volume: 4, P: 1532-1544