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Showing 1–4 of 4 results
Advanced filters: Author: Simone Nüssing Clear advanced filters

  • MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection.

    • Bonnie van Wilgenburg
    • Liyen Loh
    • Timothy S. C. Hinks
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • CD62L+ precursors of exhausted T cells retain long-term proliferative potential, multipotency and repopulation capacity, and the transcription factor MYB is essential for the development and function of this population of cells.

    • Carlson Tsui
    • Lorenz Kretschmer
    • Axel Kallies
    ResearchOpen Access
    Nature
    Volume: 609, P: 354-360

  • Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epigenetic and transcriptional identity.

    • Mayura V. Wagle
    • Stephin J. Vervoort
    • Ian A. Parish
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15