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Showing 1–8 of 8 results
Advanced filters: Author: Simone Zanoni Clear advanced filters

  • Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

    • Alexandra Barry
    • Michelle T. McNulty
    • Matthew G. Sampson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The oxytocin/oxytocin receptor (OT/OTR) signalling system is a promising therapeutic target for socioemotional disorders, yet its clinical potential is limited by a lack of in vivo molecular tools. Here, the authors develop and validate [18F]dOTK8[SFB] as a PET radiotracer, demonstrating its specificity and potential for in vivo mapping OT/OTR biodistribution.

    • Giancarlo Pascali
    • Arvind Parmar
    • Adam J. Guastella
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-14

  • Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • Lili Liu
    • Krzysztof Kiryluk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencing of blood and matched BAL cells with deep clinical, immunological and functional data.

    • Pierre Bost
    • Francesco De Sanctis
    • Vincenzo Bronte
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29