Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–16 of 16 results
Advanced filters: Author: Sinem K. Saka Clear advanced filters

  • Although many proteins adopt uneven distributions in the plasma membrane, it is not clear how these nanoscale heterogeneities relate to the general protein patterning of the membrane. Saka et al. use click chemistry to reveal the mesoscale organization of membrane proteins into multi-protein assemblies.

    • Sinem K. Saka
    • Alf Honigmann
    • Silvio O. Rizzoli
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • Secondary ion mass spectrometry is effective for imaging cellular turnover, but it cannot identify subcellular structures such as organelles. Here the authors show a method for correlating this technique with high-resolution fluorescence microscopy, enabling the measurement of turnover in cellular compartments.

    • Sinem K. Saka
    • Angela Vogts
    • Johannes T. Wessels
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

    • Oriol Pich
    • Sophia Ward
    • Nicholas McGranahan
    ResearchOpen Access
    Nature
    P: 1-11

  • Various methods, using DNA, have been reported for the recording of biomolecular interactions, but most are either destructive in nature or are limited to reporting pairwise interactions. Here the authors develop DNA-based motors, termed ‘crawlers’, that roam around and record their trajectories to allow the examination of molecular environments.

    • Sungwook Woo
    • Sinem K. Saka
    • Peng Yin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Mapping the distribution of fluorescence molecules, rather than just their emission intensity, can improve super-resolution fluorescence microscopy. Here, the authors present a general solution for rendering the number of fluorescent molecules recorded by confocal or STED microscopy.

    • Haisen Ta
    • Jan Keller
    • Stefan W. Hell
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • Using primer-exchange reactions, SABER extends FISH probes with repetitive sequences that can accommodate multiple fluorescent imager strands, resulting in up to 450-fold signal amplification. SABER is showcased in DNA and RNA FISH experiments across a range of complex biological samples.

    • Jocelyn Y. Kishi
    • Sylvain W. Lapan
    • Peng Yin
    Research
    Nature Methods
    Volume: 16, P: 533-544

  • Super-resolution microscopy has enabled optical imaging of individual biomolecules on the nanometre scale. Now, a new method has been developed that allows active manipulation of single-molecule targets on visualization in a sequential manner. This method, called ‘Action-PAINT’, combines real-time super-resolution microscopy (DNA-PAINT) and photoinducible crosslinking chemistry to deliver a single-molecule cargo with <30 nm selectivity.

    • Ninning Liu
    • Mingjie Dai
    • Peng Yin
    Research
    Nature Chemistry
    Volume: 11, P: 1001-1008

  • SpatialData is a user-friendly computational framework for exploring, analyzing, annotating, aligning and storing spatial omics data that can seamlessly handle large multimodal datasets.

    • Luca Marconato
    • Giovanni Palla
    • Oliver Stegle
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 58-62

  • Existing methods for nanoscale visualization of biological targets in thick samples require complex hardware. Here, the authors combine the standard spinning disk confocal (SDC) microscopy with DNA points accumulation for imaging in nanoscale topography (DNA-PAINT) to image proteins, DNA and RNA deep in cells.

    • Florian Schueder
    • Juanita Lara-Gutiérrez
    • Ralf Jungmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

    • Sanjay Jain
    • Liming Pei
    • Michael P. Snyder
    Reviews
    Nature Cell Biology
    Volume: 25, P: 1089-1100