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Showing 1–3 of 3 results
Advanced filters: Author: Sinisa Bratulic Clear advanced filters

  • Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations.

    • Sinisa Bratulic
    • Macarena Toll-Riera
    • Andreas Wagner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Synthetic biologists often co-opt heterologous parts to affect new functions in living cells, yet such an approach has rarely been extended to structural components of the ribosome. Here, the authors describe generalizable methods to express ribosomes from divergent microbes in E. coli and maximize their function.

    • Natalie S. Kolber
    • Ranan Fattal
    • Ahmed H. Badran
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12