Vitaliano et al. show in mice that engineered clathrin triskelia (CT) conjugated to BDNF (BDNF-CT) and delivered intranasally increases hippocampal BDNF concentrations 400-fold above that achieved previously with intranasal BDNF alone. They also show that it enhance neurogenesis, synaptogenesis and cognition in a mouse model of HIV/neuroAIDS, highlighting its potential in regenerative medicine.
- Gordana D. Vitaliano
- Jae K. Kim
- Franco Vitaliano
