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Nature Cell Biology (2)

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Advanced filters: Author: Smirthy Ganesan Clear advanced filters

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaining a robust redox ratio is key to clonal prevalence.

Anupama Hemalatha
Zongyu Li
Valentina Greco
ResearchOpen Access06 Jan 2025
Nature Cell Biology

Volume: 27, P: 218-231
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer

Cockburn et al. report that epidermal differentiation is a multi-day process through which cells undergo a continuum of transcriptional alterations initiated independently of cell cycle exit.

Katie Cockburn
Karl Annusver
Valentina Greco
ResearchOpen Access10 Nov 2022
Nature Cell Biology

Volume: 24, P: 1692-1700

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Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer

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