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Showing 1–6 of 6 results
Advanced filters: Author: Smita S. Chandran Clear advanced filters

  • While static structures can provide insight into T cell receptor (TCR) antigen specificity, this often fails and auxiliary information is needed. Here the authors show, by focusing on an HLA-A3-bound neoantigen and its WT counterpart, the allosteric formation of a peptide-dependent dynamic gate that permits selective TCR recognition of a neoantigen.

    • Jiaqi Ma
    • Cory M. Ayres
    • Brian M. Baker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • A new high-throughput platform to find rare T cells that can recognize shared cancer neoantigens identifies T cell receptors specific for a conserved, immunogenic and therapeutically actionable epitope in mutant PI3Kα, one of the most common driver oncogenes

    • Smita S. Chandran
    • Jiaqi Ma
    • Christopher A. Klebanoff
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 946-957

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411

  • The nuclear factor TOX is highly expressed in antigen-specific dysfunctional T cells in tumours and exhausted T cells during chronic viral infection and is a crucial regulator of the differentiation of tumour-specific T cells.

    • Andrew C. Scott
    • Friederike Dündar
    • Andrea Schietinger
    Research
    Nature
    Volume: 571, P: 270-274

  • T cell receptors (TCRs) enable the targeting of proteins selectively expressed by cancer cells, including neoantigens, cancer germline antigens and viral oncoproteins. This Review discusses the current cancer treatment landscape using TCRs and TCR-like molecules, including adoptive cell transfer of T cells expressing endogenous or engineered TCRs or TCR bispecific engagers.

    • Christopher A. Klebanoff
    • Smita S. Chandran
    • Antoni Ribas
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 996-1017