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Showing 1–2 of 2 results
Advanced filters: Author: Snehal Gaikwad Clear advanced filters

  • Here, the authors identify a small molecule degrader (XL44) for hRpn13 and solve the XL44-hRpn13 structure. XL44 induces apoptosis in myeloma cells with hRpn13 dependency and also targets KEN box proteins PCLAF and RRM2. Loss of hRpn13 and PCLAF abrogates XL44 restriction of cell viability.

    • Xiuxiu Lu
    • Monika Chandravanshi
    • Kylie J. Walters
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivity

    • David R. Calabrese
    • Xiang Chen
    • John S. Schneekloth Jr.
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15