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Showing 1–6 of 6 results

Advanced filters: Author: Sofie Lautrup Clear advanced filters

NAD⁺ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD⁺ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.

Evandro F. Fang
Yujun Hou
Vilhelm A. Bohr
ResearchOpen Access21 Nov 2019
Nature Communications

Volume: 10, P: 1-18
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Two potent mitophagy inducers, identified and characterized via unsupervised machine learning and a cross-species screening approach, ameliorated the pathology of Alzheimer’s disease in worms and mice.

Chenglong Xie
Xu-Xu Zhuang
Evandro F. Fang
ResearchOpen Access06 Jan 2022
Nature Biomedical Engineering

Volume: 6, P: 76-93
Enhanced brain mitophagy slows systemic aging

Compromised clearance of dysfunctional mitochondria, through the process of mitophagy, has garnered attention as an essential contributor to aging and neurodegeneration. Schmid and colleagues¹ reveal that genetic enhancement of mitophagy via neuronal overexpression of BNIP3 alleviates brain aging and prolongs healthspan in fruit flies.

Sofie Lautrup
Evandro F. Fang
News & Views17 Jun 2022
Nature Aging

Volume: 2, P: 463-464
WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.

Yuyao Tian
Wuming Wang
Wai-Yee Chan
ResearchOpen Access16 Sept 2022
Nature Communications

Volume: 13, P: 1-20
Emerging strategies, applications and challenges of targeting NAD⁺ in the clinic

Levels of the metabolic coenzyme NAD⁺ decline during aging, which is linked to many age-related diseases. Zhang et al. review recent clinical and translational evidence testing NAD⁺ supplementation in age-related diseases, highlighting therapeutic challenges and opportunities.

Jianying Zhang
He-Ling Wang
Evandro Fei Fang
Reviews09 Sept 2025
Nature Aging

Volume: 5, P: 1704-1731
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

The authors report that mitophagy is impaired in Alzheimer’s disease. Stimulation of mitophagy reverses cognitive deficits in nematode and mouse models of Alzheimer’s disease, suggesting a potential therapeutic intervention.

Evandro F. Fang
Yujun Hou
Vilhelm A. Bohr
Research11 Feb 2019
Nature Neuroscience

Volume: 22, P: 401-412