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Showing 1–3 of 3 results
Advanced filters: Author: Soline Odouard Clear advanced filters

  • Excess ketogenesis can lead to ketoacidosis, a serious complication in patients with diabetes. Here the authors report an insulin independent pathway, the hepatic nonparenchymal S100A9-TLR4-mTORC1 axis, that is able to normalize diabetic ketogenesis and pre-clinical data to suggest potential for development of S100A9 based adjunctive therapy to insulin.

    • Gloria Ursino
    • Giorgio Ramadori
    • Roberto Coppari
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Seguin et al demonstrated in glioblastoma patient-derived stem cells that a subset of glioblastoma tumours is dependent on macropinocytosis mediated survival through a Galectin-3/RAB10/beta 1 integrin axis. They used both genetic and pharmacologic inhibition of Galectin-3 in vivo and in vitro to identify underlying mechanisms and define a Galectin-3/macropinocytosis molecular signature, which could inform the development of anti-tumour therapeutic strategies.

    • Laetitia Seguin
    • Soline Odouard
    • Érika Cosset
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17