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Showing 1–2 of 2 results
Advanced filters: Author: Songting Shi Clear advanced filters

  • The apelin receptor (APJR) is a drug target for cardiovascular and metabolic health. Here, authors reveal how ligand binding, receptor dimerization, and G protein coupling cooperate to regulate APJR signaling pathway, providing insight for drug discovery.

    • Yang Yue
    • Lier Liu
    • Fei Xu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Cryo-EM analysis of the human apelin receptor activated by either the endogenous peptide ligand or a potent synthetic small-molecule agonist reveals a mixture of homodimer and monomer organizations shedding light on a versatile regulation mechanism.

    • Yang Yue
    • Lier Liu
    • Fei Xu
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 688-697