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Showing 1–4 of 4 results

Advanced filters: Author: Sonia M. Scaria Clear advanced filters

Epimorphic regeneration in the mammalian tympanic membrane

Sonia M. Scaria
Stacey M. Frumm
Aaron D. Tward
ResearchOpen Access18 Oct 2023
npj Regenerative Medicine

Volume: 8, P: 1-15
Dihydroxyacetone phosphate signals glucose availability to mTORC1

Levels of the glycolytic intermediate metabolite dihydroxyacetone phosphate are shown to signal cellular glucose availability to the mTORC1 complex through an AMPK-independent route.

Jose M. Orozco
Patrycja A. Krawczyk
David M. Sabatini
Research27 Jul 2020
Nature Metabolism

Volume: 2, P: 893-901
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Gene expression is precisely modulated with CRISPR interference and mismatched guide RNAs.

Marco Jost
Daniel A. Santos
Jonathan S. Weissman
Research13 Jan 2020
Nature Biotechnology

Volume: 38, P: 355-364
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.

Rachel L. Wolfson
Lynne Chantranupong
David M. Sabatini
Research15 Feb 2017
Nature

Volume: 543, P: 438-442