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Showing 1–9 of 9 results
Advanced filters: Author: Sophie Basler Clear advanced filters

  • The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of morphine, providing precise chronic pain relief without affecting sensory detection.

    • Corinna S. Oswell
    • Sophie A. Rogers
    • Gregory Corder
    ResearchOpen Access
    Nature
    Volume: 649, P: 938-947

  • The ubiquitin-like modifier FAT10 is composed of two ubiquitin-like domains (UBDs). Here the authors present the FAT10 UBD structures and show that the unstructured FAT10 N-terminal heptapeptide together with the poor stability of FAT10 facilitate the rapid proteasomal targeting of FAT10 along with its substrates.

    • Annette Aichem
    • Samira Anders
    • Silke Wiesner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Sophie Richard et al. present a detailed study of the development of the vasculature in the chicken embryo chorioallantoic membrane. They find that the interlacing of arteries and veins arises due to differential hemodynamic resistance acting on the distal and proximal ends of the arteries causing veins to be alternately repelled or attracted.

    • Sophie Richard
    • Amanda Brun
    • Vincent Fleury
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-11

  • A de novo designed zinc-binding protein has been converted into a highly active, stereoselective catalyst for a hetero-Diels–Alder reaction. Design and directed evolution were used to effectively harness Lewis acid catalysis and create an enzyme more proficient than other reported Diels–Alderases.

    • Sophie Basler
    • Sabine Studer
    • Donald Hilvert
    Research
    Nature Chemistry
    Volume: 13, P: 231-235

  • Recent progress in computational enzyme design, active site engineering and directed evolution are reviewed, highlighting methodological innovations needed to deliver improved designer biocatalysts.

    • Sarah L. Lovelock
    • Rebecca Crawshaw
    • Anthony P. Green
    Reviews
    Nature
    Volume: 606, P: 49-58