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Showing 1–4 of 4 results
Advanced filters: Author: Sophie Hafner Clear advanced filters

  • Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.

    • Remco V. Klaassen
    • Jasper Stroeder
    • August B. Smit
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Hormone-producing enteroendocrine cells (EEC) regulate of energy homeostasis and gastrointestinal function. Here the authors report protocols to induce human intestinal stem cells into EECs producing multiple gut hormones, including SST, 5-HT, CCK and GIP, using directed differentiation with small molecules targeting FOXO1, JNK and CB1 signalling.

    • Daniel Zeve
    • Eric Stas
    • David T. Breault
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • The authors report that neddylation is required for dendritic spine development and stability, and loss of neddylation in excitatory forebrain neurons leads to synaptic loss, impaired neurotransmission, and learning and memory deficits. The roles of neddylation in spine maturation and synaptic transmission could be attributed to neddylation of PSD-95.

    • Annette M Vogl
    • Marisa M Brockmann
    • Damian Refojo
    Research
    Nature Neuroscience
    Volume: 18, P: 239-251