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Showing 1–3 of 3 results
Advanced filters: Author: Sophie Leboucher Clear advanced filters

  • Radiation damages the healthy lung and triggers severe side effects. Here the authors provide a single cell atlas of the lung responses to radiation injury to explore the spatio-temporal dynamics of the mechanisms leading to radio-induced pulmonary fibrosis.

    • Sandra Curras-Alonso
    • Juliette Soulier
    • Charles Fouillade
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • In patient with glioblastoma, a major cause of resistance to chemotherapy and radiotherapy is the high degree to intratumoral heterogeneity and cell plasticity. Here, the authors demonstrate that chemoradiation induces the reprograming of glioblastoma cells into an invasive and vessel co-opting state, termed VC-Resist, capable of promoting resistance to therapy.

    • Cathy Pichol-Thievend
    • Oceane Anezo
    • Giorgio Seano
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • Despite being an important driver of a subset of medulloblastomas, efforts to therapeutically target Sonic Hedgehog (SHH) signaling, such as with the use of Smoothened (SMO) inhibitors, have had limited success. Here, the authors find that SHH medulloblastomas are sensitive to netrin-1 inhibition and investigate netrin-1 as a mechanism of resistance to SMO inhibition.

    • Julie Talbot
    • Joanna Fombonne
    • Olivier Ayrault
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20