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Advanced filters: Author: Sophie Levantovsky Clear advanced filters

  • Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule substrates, beyond proteins. This discovery may be harnessed to develop specific tool substrates or inhibitors of HECT-type ligases.

    • Barbara Orth
    • Pavel Pohl
    • Sonja Lorenz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19