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Showing 1–5 of 5 results
Advanced filters: Author: Sophie Ruff Clear advanced filters

  • A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

    • Ken Suzuki
    • Konstantinos Hatzikotoulas
    • Eleftheria Zeggini
    ResearchOpen Access
    Nature
    Volume: 627, P: 347-357

  • Through a chemical genetics screen and phospho-proteomics, Ledet and Ruff et al identify substrates of the oncogenic kinase PIM1 in prostate cancer cells. They find that NDRG1 protein is destabilized by PIM1-mediated phosphorylation to reduce its metastasis suppressor function. These findings shed light on the role of PIM1 in prostate cancer.

    • Russell J. Ledet
    • Sophie E. Ruff
    • Michael J. Garabedian
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and increasing remyelination efficiency.

    • Mert Duman
    • Adrien Vaquié
    • Claire Jacob
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Ruff et al. demonstrate that phosphorylation of the androgen receptor and 14-3-3 ζ by PIM1 kinase coordinates their interaction and chromatin occupancy at genes involved in cell migration and invasion. The authors conclude that PIM1 phosphorylation of these substrates regulates the AR transcriptome in prostate cancer cells.

    • Sophie E. Ruff
    • Nikita Vasilyev
    • Michael J. Garabedian
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15