Nature Search

Publisher Correction: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Pradipta Ghosh
Gajanan D. Katkar
Debashis Sahoo
Amendments and CorrectionsOpen Access11 Aug 2022
Nature Communications

Volume: 13, P: 1
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

The understudied lipid kinase PIP4K2C binds SARS-CoV-2 nonstructural protein 6 and regulates virus-induced autophagic flux impairment, suppressing viral protein degradation. PIP4K2C inhibition is a candidate strategy to combat emerging viruses.

Marwah Karim
Manjari Mishra
Shirit Einav
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Linking SARS-CoV-2 to the circadian clock

A study using a multi-organoid platform and state-of-the-art transcriptional profiling identifies potential therapeutic targets against SARS-CoV-2. The authors find that CIART, a gene involved in circadian regulation, promotes SARS-CoV-2 infection by regulating the retinoid X receptor pathway and fatty acid synthesis.

Soumita Das
News & Views13 Mar 2023
Nature Cell Biology

Volume: 25, P: 373-374
Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease.

Debashis Sahoo
Lee Swanson
Pradipta Ghosh
ResearchOpen Access12 Jul 2021
Nature Communications

Volume: 12, P: 1-14
SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for Pol II elongation, and SPT6 loss leads to an intestine-like phenotype.

Jingting Li
Xiaojun Xu
George L. Sen
ResearchOpen Access04 Feb 2021
Nature Communications

Volume: 12, P: 1-15
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions

Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.

Malina A. Bakowski
Nathan Beutler
Thomas F. Rogers
ResearchOpen Access03 Jun 2021
Nature Communications

Volume: 12, P: 1-14
The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection

NEIL2, a mammalian DNA repair enzyme, has been reported to suppress infection induced inflammation. Here, the authors characterize its role in modulating the severity of SARS-CoV-2 infection.

Nisha Tapryal
Anirban Chakraborty
Tapas K. Hazra
ResearchOpen Access09 Dec 2023
Nature Communications

Volume: 14, P: 1-16
An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Multisystem inflammatory syndrome may occur in children following COVID-19 infection. Here, the authors analyze gene signatures to show that MIS-C shares the same host immune response as the pre-pandemic inflammatory syndrome of Kawasaki disease but is further along in the spectrum in disease severity

Pradipta Ghosh
Gajanan D. Katkar
Debashis Sahoo
ResearchOpen Access16 May 2022
Nature Communications

Volume: 13, P: 1-18
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

Daeho Park
Claudia Z. Han
Kodi S. Ravichandran
Research21 Aug 2011
Nature

Volume: 477, P: 220-224
Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

A Boolean network explorer (BoNE) computational algorithm was used to identify a dual agonist of the nuclear receptors PPARα and PPARγ that may be therapeutic in treating inflammatory bowel disease.

Gajanan D. Katkar
Ibrahim M. Sayed
Pradipta Ghosh
ResearchOpen Access14 Mar 2022
Communications Biology

Volume: 5, P: 1-21

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