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Generation of human T lymphocytes from bone marrow CD34⁺ cells in vitro

Andrew R. Freedman
Haihong Zhu
David T. Scadden
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 46-51
Antiviral CD4⁺ T and myeloid cell responses to influenza vaccines are attenuated in older adults

Oakes et al., evaluated cellular and humoral immune responses after influenza vaccinations in adults. Vaccination elicited comparable serologic responses; however, adults 65 years old and over had reduced cellular immune responses, and single-cell RNA sequence analysis revealed that they had attenuated IFN transcriptional signatures in T-helper and myeloid cell subsets.

Jared M. Oakes
Joshua D. Simmons
Spyros A. Kalams
ResearchOpen Access17 Apr 2026
Communications Medicine

P: 1-15
Efficient generation of human T cells from a tissue-engineered thymic organoid

Mark C. Poznansky
Richard H. Evans
David T. Scadden
Research01 Jul 2000
Nature Biotechnology

Volume: 18, P: 729-734
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

Kathleen L. Collins
Benjamin K. Chen
David Baltimore
Research22 Jan 1998
Nature

Volume: 391, P: 397-401
β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

Ludwig Wagner
Otto O. Yang
Andrew D. Luster
Research26 Feb 1998
Nature

Volume: 391, P: 908-911
Omicron COVID-19 immune correlates analysis of a third dose of mRNA-1273 in the COVE trial

Using data from a phase 3 efficacy trial, the authors here show that post-boost Omicron BA.1 spike-specific binding and neutralizing antibodies inversely correlate with Omicron COVID-19 and booster efficacy for naive and non-naive participants, supporting the continued use of antibody as a surrogate endpoint.

Bo Zhang
Youyi Fong
Lars W. P. van der Laan
ResearchOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening severe cutaneous drug reaction mediated by CD8⁺ T cells. Here the authors characterise the immune response in skin samples at the site of tissue damage from patients affected with SJS/TEN and compare this to healthy skin or blister fluid and find populations of CD8⁺ T cell clonotypes expressing cytotoxic mediator molecules.

Andrew Gibson
Ramesh Ram
Elizabeth J. Phillips
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Evidence of CD4⁺ T cell-mediated immune pressure on the Hepatitis C virus genome

Michaela Lucas
Pooja Deshpande
Silvana Gaudieri
ResearchOpen Access08 May 2018
Scientific Reports

Volume: 8, P: 1-10

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Generation of human T lymphocytes from bone marrow CD34⁺ cells in vitro

Antiviral CD4⁺ T and myeloid cell responses to influenza vaccines are attenuated in older adults

Efficient generation of human T cells from a tissue-engineered thymic organoid

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

Omicron COVID-19 immune correlates analysis of a third dose of mRNA-1273 in the COVE trial

Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis

Evidence of CD4⁺ T cell-mediated immune pressure on the Hepatitis C virus genome

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