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Showing 1–6 of 6 results
Advanced filters: Author: Sreejith J. Varma Clear advanced filters

  • The acetyl-CoA pathway is the most ancient CO2 fixation pathway in nature. Here, the authors show that metals selectively reduce CO2 to the intermediates and end-products of the acetyl-CoA pathway, which is consistent with a prebiotic origin of this pathway.

    • Sreejith J. Varma
    • Kamila B. Muchowska
    • Joseph Moran
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 1019-1024

  • Systematically culturing combinations of auxotrophic yeast mutants leads to the identification of pairs that form obligatory cross-feeding relationships, some of which are stable over time and can divide metabolic labor for biotechnological applications.

    • Simran Kaur Aulakh
    • Lara Sellés Vidal
    • Rodrigo Ledesma-Amaro
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 951-961

  • The reverse Krebs cycle is a potential primordial anabolic pathway central to biochemistry. Here, the authors show that more than half of the cycle can be promoted by metals and metal ions without enzymes.

    • Kamila B. Muchowska
    • Sreejith J. Varma
    • Joseph Moran
    Research
    Nature Ecology & Evolution
    Volume: 1, P: 1716-1721

  • A chemical reaction network that overlaps with the biological Krebs and glyoxylate cycles arises from pyruvate and glyoxylate in the presence of iron, suggesting how early metabolic pathways might have arisen from CO2.

    • Kamila B. Muchowska
    • Sreejith J. Varma
    • Joseph Moran
    Research
    Nature
    Volume: 569, P: 104-107