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Evaluation of N-Desmethylclozapine as a Potential Antipsychotic—Preclinical Studies

Sridhar Natesan
Greg E Reckless
Shitij Kapur
Research13 Dec 2006
Neuropsychopharmacology

Volume: 32, P: 1540-1549
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [¹¹C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.

Ellis Chika Onwordi
Els F. Halff
Oliver D. Howes
ResearchOpen Access14 Jan 2020
Nature Communications

Volume: 11, P: 1-11
The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study

Ellis Chika Onwordi
Thomas Whitehurst
Oliver D. Howes
ResearchOpen Access01 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-8
The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Ellis Chika Onwordi
Thomas Whitehurst
Oliver D. Howes
ResearchOpen Access17 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-9
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine

Michelle Kokkinou
Elaine E. Irvine
Oliver D. Howes
ResearchOpen Access07 May 2020
Molecular Psychiatry

Volume: 26, P: 2562-2576
Dissociation between In Vivo Occupancy and Functional Antagonism of Dopamine D₂ Receptors: Comparing Aripiprazole to Other Antipsychotics in Animal Models

Sridhar Natesan
Greg E Reckless
Shitij Kapur
Research30 Nov 2005
Neuropsychopharmacology

Volume: 31, P: 1854-1863

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Evaluation of N-Desmethylclozapine as a Potential Antipsychotic—Preclinical Studies

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine

Dissociation between In Vivo Occupancy and Functional Antagonism of Dopamine D2 Receptors: Comparing Aripiprazole to Other Antipsychotics in Animal Models

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Dissociation between In Vivo Occupancy and Functional Antagonism of Dopamine D₂ Receptors: Comparing Aripiprazole to Other Antipsychotics in Animal Models