The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits formation of a functional viral replication complex.
- Chen Zhao
- Haripriya Sridharan
- Robert M. Krug
