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Showing 1–4 of 4 results
Advanced filters: Author: Srirupa Chakraborty Clear advanced filters

  • Structurally resolving glycans remains a challenge. Here, the authors analyse influenza H3 hemagglutinin glycan evolution to show that over five decades of glycan incorporation highly impact structural stability and epitope accessibility, particularly in the head domain, providing key insights for vaccine design.

    • Rebeca de Paiva Froes Rocha
    • Ilhan Tomris
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when swapped exchange function between adult and fetal AChRs.

    • Tapan Kumar Nayak
    • Srirupa Chakraborty
    • Anthony Auerbach
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in passive transfer studies in macaques. The nAb was used to provide the first high-resolution structure of a rhesus SIV trimer by CryoEM. Analysis of the glycosylation pattern of this SIV trimer suggests a denser glycan shield on Env for rhesus SIV compared to chimpanzee SIV or HIV-1, which partially explains the poor nAb response of rhesus macaques to SIVmac239 infection.

    • Fangzhu Zhao
    • Zachary T. Berndsen
    • Devin Sok
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16