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Showing 1–6 of 6 results
Advanced filters: Author: Sruti Shiva Clear advanced filters

  • Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

    • Jon O Lundberg
    • Mark T Gladwin
    • Eddie Weitzberg
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 865-869

  • Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics.

    • Mark T Gladwin
    • Alan N Schechter
    • Jon O Lundberg
    News & Views
    Nature Chemical Biology
    Volume: 1, P: 308-314

  • Macrophages and their metabolism are known to contribute to inflammation in the atherosclerotic plaques, but the underpinning molecular level regulatory processes are lesser known. Here authors show that under inflammatory conditions, macrophages express VCAM-1 within the atherosclerotic plaques, which leads to increased mitochondrial DNA synthesis via activation of the transcription factor C/EBPα, which in turn triggers inflammation by STING signalling.

    • Niranjana Natarajan
    • Jonathan Florentin
    • Partha Dutta
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The physiological role of crosstalk between mesenchymal stem cells (MSC) and macrophages is unclear. Here, Phinney et al. show that MSCs transfer mitochondria to macrophages under oxidative stress, and desensitize macrophages to mitochondria by using microvesicles to repress Toll receptor signalling.

    • Donald G. Phinney
    • Michelangelo Di Giuseppe
    • Luis A. Ortiz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15