Two different G-protein-coupled receptor families are known to mediate pheromonal cues in the mammalian vomeronasal organ. Here, members of a third family of receptors, the formyl peptide receptor-related gene family (FPRs), are shown to be expressed in the vomeronasal epithelium, with those cells expressing FPRs responding to ligands associated with disease and inflammation. This raises the possibility that FPRs detect the health status of individuals.
- Stéphane Rivière
- Ludivine Challet
- Ivan Rodriguez