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Showing 1–6 of 6 results
Advanced filters: Author: Stéphane Rosset Clear advanced filters

  • A deep-learning-based de novo design strategy was developed that enables simultaneous scaffolding of three distinct epitopes derived from respiratory syncytial virus within small single-domain immunogens. Crystallographic analyses confirmed precise presentation of the designed motifs. The multiepitope constructs elicited enhanced cross-reactive and neutralizing antibody responses, demonstrating the potential of generative models for complex multisite protein engineering.

    • Karla M. Castro
    • Joseph L. Watson
    • Bruno E. Correia
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-8

  • A deep learning approach enables accurate computational design of soluble and functional analogues of membrane proteins, expanding the soluble protein fold space and facilitating new approaches to drug screening and design.

    • Casper A. Goverde
    • Martin Pacesa
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 631, P: 449-458

  • Beginning with a functional site and building a supporting scaffold around it enables the de novo design of proteins with distinct binding motifs for use in biosensors to detect antibody responses and as ligands of synthetic signaling receptors.

    • Che Yang
    • Fabian Sesterhenn
    • Bruno E. Correia
    Research
    Nature Chemical Biology
    Volume: 17, P: 492-500

  • Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.

    • Sailan Shui
    • Pablo Gainza
    • Bruno E. Correia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Domain insertion into the loop region of AcrIIC1 leads to a variant with enhanced inhibitory activity toward Neisseria meningitides Cas9, while structure-guided design turns AcrIIC1 into a potent inhibitor of Staphylococcus aureus Cas9.

    • Jan Mathony
    • Zander Harteveld
    • Dominik Niopek
    Research
    Nature Chemical Biology
    Volume: 16, P: 725-730

  • A surface-centric approach captures the physical and chemical determinants of molecular recognition, enabling the de novo design of protein interactions and of artificial proteins with function.

    • Pablo Gainza
    • Sarah Wehrle
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 617, P: 176-184