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Showing 1–5 of 5 results
Advanced filters: Author: Stéphane Y. Corbel Clear advanced filters

  • To elucidate regulatory mechanisms involved in reprogramming to generate pluripotent cells from somatic cells, this study generates interspecies heterokaryons (fused mouse ES cells and human fibroblasts) that induce reprogramming efficiently, rapidly and without cell division. SiRNA–mediated knockdown reveals that AID is required for active DNA demethylation and initiation of nuclear reprogramming towards pluripotency in human somatic cells.

    • Nidhi Bhutani
    • Jennifer J. Brady
    • Helen M. Blau
    Research
    Nature
    Volume: 463, P: 1042-1047

  • The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired muscle regeneration following injury in mice.

    • Srinath C. Sampath
    • Srihari C. Sampath
    • Helen M. Blau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cytoskeletal rearrangement and cell fusion even in non-muscle cells.

    • Qiao Zhang
    • Ajay A. Vashisht
    • Srihari C. Sampath
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15