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Showing 1–7 of 7 results
Advanced filters: Author: Stacey L. Rentschler Clear advanced filters

  • Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.

    • David M. Zhang
    • Rachita Navara
    • Stacey L. Rentschler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Spatially resolved multiomics is an emerging approach for profiling gene expression at the cellular level while maintaining the spatial organization of tissues. Its application in healthy human hearts provides insight into ion channels and regulatory signaling in the cardiac conduction system, cardiac cellular niches and drug–cell interactions.

    • Samuel Jordan
    • Stacey L. Rentschler
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 798-800

  • Secondary acute myeloid leukemias (sAMLs) evolving from myeloproliferative neoplasms (MPNs) associate with poor prognosis. Here authors identify RSK1 as a vulnerability for MPN and sAML and show the efficacy of a first-in-class RSK inhibitor, PMD-026, against these types of myeloid malignancies.

    • Tim Kong
    • Angelo B. A. Laranjeira
    • Stephen T. Oh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to treat heart injury.

    • Ramón Díaz-Trelles
    • Maria Cecilia Scimia
    • Mark Mercola
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Koenig et al. present integrated single-cell and single-nucleus RNA-sequencing data of cardiac samples obtained from 27 healthy donors and 18 individuals with dilated cardiomyopathy. This extensive resource provides insights on cell composition and gene expression changes driven by the disease status, sex or age of the patients.

    • Andrew L. Koenig
    • Irina Shchukina
    • Kory J. Lavine
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 263-280