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Showing 1–17 of 17 results
Advanced filters: Author: Stacy M. Ku Clear advanced filters

  • Chronic social-defeat stress increases phasic firing of ventral tegmental area (VTA) neurons and increases the amount of BDNF in the nucleus accumbens (NAc). The authors show that increased activity of NAc-projecting VTA neurons is sufficient to increase the amount of BDNF in the NAc, an effect that depends on CRF signaling in the NAc.

    • Jessica J Walsh
    • Allyson K Friedman
    • Ming-Hu Han
    Research
    Nature Neuroscience
    Volume: 17, P: 27-29

  • Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.

    • Allyson K. Friedman
    • Barbara Juarez
    • Ming-Hu Han
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • The influence of climate on premodern civil conflict and societal instability is debated. Here, the authors combine archeological, historical, and paleoclimatic datasets to show that drought between 1400-1450 cal. CE escalated civil conflict at Mayapan, the largest Postclassic Maya capital of the Yucatán Peninsula.

    • Douglas J. Kennett
    • Marilyn Masson
    • David A. Hodell
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.

    • Juan Pablo Lopez
    • Laura M. Fiori
    • Gustavo Turecki
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • Dick Schijven
    • Michael C. O’Donovan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights the involvement of the immune system in disease pathogenesis.

    • Lohith Madireddy
    • Nikolaos A. Patsopoulos
    • Sergio E. Baranzini
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

    • Muralidharan Sargurupremraj
    • Hideaki Suzuki
    • Stéphanie Debette
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Polycomb repressive complex 2 (PRC2) is a key mammalian epigenetic regulator that supports neuron specification during development. In this paper, the authors find that PRC2 plays a role in the survival of adult neurons. The loss of PRC2 activity in adult striatum led to the de-repression of multiple genes with bivalent histone methylation marks and to a fatal neurodegeneration phenotype.

    • Melanie von Schimmelmann
    • Philip A Feinberg
    • Anne Schaefer
    Research
    Nature Neuroscience
    Volume: 19, P: 1321-1330

  • A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.

    • Adil Harroud
    • Pernilla Stridh
    • Kári Stefánsson
    Research
    Nature
    Volume: 619, P: 323-331

  • Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice, suppresses alcohol drinking in mice that are high alcohol drinking.

    • Barbara Juarez
    • Carole Morel
    • Ming-Hu Han
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • While making up a small percentage of neurons in the nucleus accumbens, somatostatin interneurons may have important function in dopamine- and addiction-related behavior. Here, Ribeiro and colleagues show that somatostatin interneurons regulate behavioral responses to cocaine with physiological and transcriptomic changes.

    • Efrain A. Ribeiro
    • Marine Salery
    • Eric J. Nestler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

    • Dipesh Chaudhury
    • Jessica J. Walsh
    • Ming-Hu Han
    Research
    Nature
    Volume: 493, P: 532-536

  • The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into the immune system processes underlying this disease.

    • Ashley H Beecham
    • Nikolaos A Patsopoulos
    • Jacob L McCauley
    Research
    Nature Genetics
    Volume: 45, P: 1353-1360