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Advanced filters: Author: Stamatis Papathanasiou Clear advanced filters

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

Chromothripsis, a chromosomal shattering event, can be elicited by micronuclei and chromosome bridges formed by CRISPR–Cas9-generated double-stranded breaks. Extensive chromosomal rearrangements may thus be an on-target effect of genome editing.

Mitchell L. Leibowitz
Stamatis Papathanasiou
David Pellman
Research12 Apr 2021
Nature Genetics

Volume: 53, P: 895-905
Heritable transcriptional defects from aberrations of nuclear architecture

Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between chromosomal instability and variation in chromatin state and gene expression.

Stamatis Papathanasiou
Nikos A. Mynhier
David Pellman
ResearchOpen Access07 Jun 2023
Nature

Volume: 619, P: 184-192
Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.

Stamatis Papathanasiou
Styliani Markoulaki
David Pellman
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-7
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18

The cytokine TNF-α, typically considered to have deleterious effects on the heart, can also have cardioprotective effects by inducing formation of a keratin cytoskeletal network in cardiomyocytes.

Stamatis Papathanasiou
Steffen Rickelt
Yassemi Capetanaki
Research17 Aug 2015
Nature Medicine

Volume: 21, P: 1076-1084
Autologous CAR T-cell therapies supply chain: challenges and opportunities?

Maria M. Papathanasiou
Christos Stamatis
Nilay Shah
Research14 Jan 2020
Cancer Gene Therapy

Volume: 27, P: 799-809