Nature Search

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

Charlotte Givord
Iain Welsby
Stanislas Goriely
ResearchOpen Access28 Jun 2018
npj Vaccines

Volume: 3, P: 1-12
How microorganisms tip the balance between interleukin-12 family members

Distinct members of the interleukin-12 (IL-12) cytokine family can differentially regulate T-cell-mediated inflammation. In this Opinion article, the authors propose that microbial products and endogenous mediators can control the balance between these cytokines, thereby directly regulating the inflammatory response.

Stanislas Goriely
Markus F. Neurath
Michel Goldman
Reviews01 Jan 2008
Nature Reviews Immunology

Volume: 8, P: 81-86
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.

Nicolas Istaces
Marion Splittgerber
Abdulkader Azouz
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-17
Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer

Meggy Suarez-Carmona
Mareike Hampel
Niels Halama
ResearchOpen Access04 Mar 2026
Signal Transduction and Targeted Therapy

Volume: 11, P: 1-20
The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis

Caroline La
Bérengère de Toeuf
Stanislas Goriely
Research28 May 2020
Mucosal Immunology

Volume: 14, P: 80-91
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis

Knowledge about the ontogeny of T cells in the thymus relies heavily on mouse studies because of difficulty to obtain human material. Here the authors perform a single cell analysis of thymocytes from human fetal and paediatric thymic samples to characterise the development of human γδ T cells in the thymus.

Guillem Sanchez Sanchez
Maria Papadopoulou
David Vermijlen
ResearchOpen Access04 Oct 2022
Nature Communications

Volume: 13, P: 1-19
An innate antiviral pathway acting before interferons at epithelial surfaces

Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a hyperacute innate immune response that precedes even the production of type I interferons.

Marie B Iversen
Line S Reinert
Søren R Paludan
Research30 Nov 2015
Nature Immunology

Volume: 17, P: 150-158
Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8⁺ T cells

Eomesodermin is the key transcription factor for the development of ‘virtual memory’ T cells that develop in the absence of antigen-driven activation. Here the authors show that type I interferons directly activate eomesodermin and contribute to the homeostasis of virtual memory CD8⁺T cells.

Valérie Martinet
Sandrine Tonon
Stanislas Goriely
ResearchOpen Access08 May 2015
Nature Communications

Volume: 6, P: 1-13
Central Role of CD169⁺ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

Sophie Detienne
Iain Welsby
Arnaud M. Didierlaurent
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Nicolas Gemander
Julika Neumann
Stephanie Humblet-Baron
ResearchOpen Access01 Jul 2025
npj Vaccines

Volume: 10, P: 1-15
Monocytes undergo multi-step differentiation in mice during oral infection by Toxoplasma gondii

Detavernier et al. show that localized waves of epigenetic programming regulate the differentiation process of Ly6C^hi monocytes during oral infection by Toxoplasma gondii, which are dominated by STAT1 in the bone marrow and AP-1/NF-kB in the periphery. This study provides insight into how monocytes are differentiated in response to inflammatory cues.

Aurélie Detavernier
Abdulkader Azouz
Stanislas Goriely
ResearchOpen Access18 Dec 2019
Communications Biology

Volume: 2, P: 1-14
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Margherita Coccia
Catherine Collignon
Arnaud M. Didierlaurent
ResearchOpen Access08 Sept 2017
npj Vaccines

Volume: 2, P: 1-14
Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Margherita Coccia
Catherine Collignon
Arnaud M. Didierlaurent
Amendments and CorrectionsOpen Access21 Mar 2018
npj Vaccines

Volume: 3, P: 1

Search

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

How microorganisms tip the balance between interleukin-12 family members

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer

The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis

Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis

An innate antiviral pathway acting before interferons at epithelial surfaces

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8⁺ T cells

Central Role of CD169⁺ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Monocytes undergo multi-step differentiation in mice during oral infection by Toxoplasma gondii

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Search

Quick links

Search

Filter By:

Search

Quick links