Nature Search

Divergent effects of intrinsically active MEK variants on developmental Ras signaling

Stanislav Shvartsman and colleagues quantify signaling changes caused by disease-associated mutations in MAP2K1 (encoding MEK) in fruit fly and zebrafish embryos. They find that intrinsically active MEK variants can both increase and reduce the levels of pathway activation depending on cellular context.

Yogesh Goyal
Granton A Jindal
Stanislav Y Shvartsman
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 465-469
A microfluidic array for large-scale ordering and orientation of embryos

A microfluidic embryo-trap array for large-scale end-on imaging of Drosophila melanogaster embryos permits quantitative analysis of dorsoventral gradients during development.

Kwanghun Chung
Yoosik Kim
Hang Lu
Research26 Dec 2010
Nature Methods

Volume: 8, P: 171-176
Publisher Correction: Mechanics of a multilayer epithelium instruct tumour architecture and function

Vincent F. Fiore
Matej Krajnc
Elaine Fuchs
Amendments and Corrections11 Sept 2020
Nature

Volume: 586, P: E9
Publisher Correction: Entropic effects in cell lineage tree packings

Jasmin Imran Alsous
Paul Villoutreix
Jörn Dunkel
Amendments and Corrections08 Aug 2018
Nature Physics

Volume: 14, P: 967
Self-organized intracellular twisters

Cytoplasmic flows in the fruit fly oocyte can reorganize cellular components. These structured vortical flows arise through self-organizing dynamics of microtubules, molecular motors and cytoplasm.

Sayantan Dutta
Reza Farhadifar
Michael J. Shelley
Research25 Jan 2024
Nature Physics

Volume: 20, P: 666-674
Entropic effects in cell lineage tree packings

The organization of small clusters of connected cells confined to an egg chamber during early development can be mapped onto a tree packing problem. Entropically preferred packing configurations are shown to arise more readily in experiment.

Jasmin Imran Alsous
Paul Villoutreix
Jörn Dunkel
Research16 Jul 2018
Nature Physics

Volume: 14, P: 1016-1021
Forced and spontaneous symmetry breaking in cell polarization

A spectrally accurate numerical method for solving partial differential equations (PDEs) on non-uniformly curved surfaces is developed. The method is applied to a PDE model of cell polarization to show that geometric effects allow the existence of unexpected multidomain solutions.

Pearson W. Miller
Daniel Fortunato
Stanislav Shvartsman
Research22 Aug 2022
Nature Computational Science

Volume: 2, P: 504-511
Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

Daryl E. Klein
Valerie M. Nappi
Mark A. Lemmon
Research26 Aug 2004
Nature

Volume: 430, P: 1040-1044
A multifunctional Wnt regulator underlies the evolution of rodent stripe patterns

Combining transcriptomics, mathematical modelling and in vivo gene editing, this study shows that Sfrp2 contributes to stripe formation and hair colour in the African striped mouse.

Matthew R. Johnson
Sha Li
Ricardo Mallarino
Research09 Oct 2023
Nature Ecology & Evolution

Volume: 7, P: 2143-2159
Mechanics of a multilayer epithelium instruct tumour architecture and function

Mathematical and experimental approaches are used to investigate the mechanical forces that shape the tumour architecture of two different common forms of skin cancer: basal cell carcinomas and invasive squamous cell carcinomas.

Vincent F. Fiore
Matej Krajnc
Elaine Fuchs
Research02 Sept 2020
Nature

Volume: 585, P: 433-439
From complex datasets to predictive models of embryonic development

A computational approach to predictive modeling of embryonic development is presented and validated by integrating imaging, biochemical and genetic studies of tissue patterning in Drosophila embryogenesis.

Sayantan Dutta
Aleena L. Patel
Stanislav Y. Shvartsman
Research20 Aug 2021
Nature Computational Science

Volume: 1, P: 516-520
Clonal dominance in excitable cell networks

As tissues grow, a small fraction of cells can give rise to a large fraction of the tissue. A model borrowed from forest fires suggests that this can occur spontaneously in development as a collective property of the cell interaction network.

Jasmin Imran Alsous
Jan Rozman
Stanislav Y. Shvartsman
Research01 Nov 2021
Nature Physics

Volume: 17, P: 1391-1395
Microfluidic trap array for massively parallel imaging of Drosophila embryos

Thomas J Levario
Mei Zhan
Hang Lu
Protocols14 Mar 2013
Nature Protocols

Volume: 8, P: 721-736
An integrated platform for large-scale data collection and precise perturbation of live Drosophila embryos

Thomas J. Levario
Charles Zhao
Hang Lu
ResearchOpen Access11 Feb 2016
Scientific Reports

Volume: 6, P: 1-12

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Divergent effects of intrinsically active MEK variants on developmental Ras signaling

A microfluidic array for large-scale ordering and orientation of embryos

Publisher Correction: Mechanics of a multilayer epithelium instruct tumour architecture and function

Publisher Correction: Entropic effects in cell lineage tree packings

Self-organized intracellular twisters

Entropic effects in cell lineage tree packings

Forced and spontaneous symmetry breaking in cell polarization

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

A multifunctional Wnt regulator underlies the evolution of rodent stripe patterns

Mechanics of a multilayer epithelium instruct tumour architecture and function

From complex datasets to predictive models of embryonic development

Clonal dominance in excitable cell networks

Microfluidic trap array for massively parallel imaging of Drosophila embryos

An integrated platform for large-scale data collection and precise perturbation of live Drosophila embryos

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