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Showing 1–9 of 9 results
Advanced filters: Author: Stanley Ching-Cheng Huang Clear advanced filters

  • Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory function and promoting immune evasion and tumorigenesis.

    • Haoxin Zhao
    • Jaeoh Park
    • Stanley Ching-Cheng Huang
    Research
    Nature Immunology
    Volume: 26, P: 2185-2200

  • A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

    • Yi Wang
    • Anjun Ma
    • Zihai Li
    ResearchOpen Access
    Nature
    Volume: 647, P: 1025-1035

  • Tumor-associated macrophages support an immunosuppressive tumor microenvironment. Di Conza et al. uncover how IRE1–XBP1 and IRE1−STAT3 endoplasmic reticulum stress responses pathways are engaged by tumor-derived lipids to orchestrate pro-tumorigenic features and survival in tumor-associated macrophages.

    • Giusy Di Conza
    • Chin-Hsien Tsai
    • Ping-Chih Ho
    Research
    Nature Immunology
    Volume: 22, P: 1403-1415

  • Alternatively activated (M2) macrophages use fatty acid oxidation for their metabolic needs. Pearce and colleagues show that triacylglycerols metabolized by lysosomal acid lipase are required for the M2 activation of and function of macrophages.

    • Stanley Ching-Cheng Huang
    • Bart Everts
    • Edward J Pearce
    Research
    Nature Immunology
    Volume: 15, P: 846-855

  • Activation of dendritic cells induces a metabolic switch from oxidative phosphorylation to glycolysis. Pearce and colleagues show TLR signaling rapidly induces glycolysis by activating a TBK1–IKKε–Akt–HK-II kinase cascade to support the fatty acid synthesis required for the activation of dendritic cells.

    • Bart Everts
    • Eyal Amiel
    • Edward J Pearce
    Research
    Nature Immunology
    Volume: 15, P: 323-332

  • Activation of the unfolded protein response during immune cell activation has emerged as making an essential contribution to the response to infection and inflammation. In this Review, the authors discuss where, how and when a disbalanced unfolded protein response can become pathological and thus a potential therapeutic target.

    • Giusy Di Conza
    • Ping-Chih Ho
    • Stanley Ching-Cheng Huang
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 546-562

  • The metabolic conditions in tumours can result in phenotypic reprogramming of non-tumour cells, including immune cells, in the tumour microenvironment. This Review provides an overview of the pathways of cancer metabolism that intersect with immunometabolism, typically resulting in immunosuppression, with a focus on how these metabolic pathways could be targeted in order to enhance anticancer immunity and immunotherapy.

    • Xiaoyun Li
    • Mathias Wenes
    • Ping-Chih Ho
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 16, P: 425-441