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Showing 1–6 of 6 results
Advanced filters: Author: Stavroula K. Hatzios Clear advanced filters

  • As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” — here is what they said.

    • Lona M. Alkhalaf
    • Cheryl Arrowsmith
    • Georg Winter
    Special Features
    Nature Chemical Biology
    Volume: 21, P: 6-15

  • Chemical proteomics analysis of human gastric cells revealed that infection with the stomach bacterium Helicobacter pylori decreases reactivity of legumain Cys219, which alters legumain processing and promotes xenograft tumor growth.

    • Yekaterina Kovalyova
    • Daniel W. Bak
    • Stavroula K. Hatzios
    Research
    Nature Chemical Biology
    Volume: 18, P: 698-705

  • Medicinal drugs can cross-react with gut bacterial proteins, but the identification of these off-target interactions is difficult. Multi-omic approaches enabled the discovery of a bacterial peptidase that is inhibited by diabetic drugs and unexpectedly influences bacterial fitness within complex microbial communities via a non-proteolytic mechanism.

    • Stavroula K. Hatzios
    News & Views
    Nature Chemical Biology
    Volume: 19, P: 1436-1437

  • An outbreak of diarrhoea and haemolytic uraemic syndrome in Germany in 2011 was caused by a Shiga toxin-producing enteroaggregative E. coli, which carried the aggregative adherence plasmid pAA. Here, the authors show that autotransporters, but not pAA, are required for intestinal colonization in an infant rabbit model.

    • Diana Munera
    • Jennifer M. Ritchie
    • Matthew K. Waldor
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • Four secreted bacterial serine hydrolases found by an ABPP approach in Vibrio cholerae–infected rabbits, and one in human infection, regulate the levels of intelectin, an intestinal lectin that binds V. cholerae during infection and may facilitate bacterial surveillance in the intestine.

    • Stavroula K Hatzios
    • Sören Abel
    • Matthew K Waldor
    Research
    Nature Chemical Biology
    Volume: 12, P: 268-274