In a mouse model of systemic autoimmunity, the damage-associated molecular pattern molecules Mrp8 and Mrp14 are essential for the induction of autoreactive CD8+ T cells and for disease development in a TLR4– and IL-17–dependent manner. A similar mechanism might be at play in people with cutaneous lupus erythematosus.
- Karin Loser
- Thomas Vogl
- Stefan Beissert
